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Garrouste C., Le J., Maurin E. (2011), The Choice of Detecting Down Syndrome: Does Money Matter?, Health Economics, 20, 9, p. 1073-1089

The prenatal diagnosis of Down syndrome (amniocentesis) presents parents with a complex dilemma which requires comparing the risk of giving birth to an affected child and the risk of losing an unaffected child through amniocentesis-related miscarriage. Building on the specific features of the French Health insurance system, this paper shows that variation in the monetary costs of the diagnosis procedure may have a very significant impact on how parents solve this ethical dilemma. The French institutions make it possible to compare otherwise similar women facing very different reimbursement schemes and we find that eligibility to full reimbursement has a largely positive effect on the probability of taking an amniocentesis test. By contrast, the sole fact of being labelled 'high-risk' by the Health system seems to have, as such, only a modest effect on subsequent choices. Finally, building on available information on post-amniocentesis outcomes, we report new evidence suggesting that amniocentesis increases the risk of premature birth and low weight at birth.

Lerouvreur C., Maurel F., Le Pen C., Hamonet C., Queneau P., Calmels P., Thoumie P. (2009), Effectiveness of a Lumbar Belt in Subacute Low Back Pain: An Open, Multicentric, and Randomized Clinical Study, Spine, 34, 3, p. 215-220

Study Design. Multicentric, randomized, and controlled study of clinical evaluation of medical device in subacute low back pain. Objective. To evaluate the effects of an elastic lumbar belt on functional capacity, pain intensity in low back pain treatment, and the benefice on medical cost. Summary of Background Data. There is limited evidence of efficiency of lumbar supports for treatment of low back pain. There is also a lack of the methodology in the studies reported on the efficiency of this device. Methods. This study is randomized, multicentric, and controlled with 2 groups: a patient group treated with a lumbar belt (BWG) and a control group (CG). The main criteria of clinical evaluation were the physical restoration assessed with the EIFEL scale, the pain assessed by a visual analogic scale, the main economical criteria was the overall cost of associated medical treatments. Results. One hundred ninety-seven patients have participated. The results show a higher decrease in EIFEL score in BWG than CG between days 0 and 90 (7.6 ± 4.4 vs. de 6.1 ± 4.7;P = 0.023). Respectively significant reduction in visual analogic scale was also noticed (41.5 ± 21.4 vs. 32.0 ± 20; P = 0.002). Pharmacologic consumption decreased at D90 (the proportion of patients who did not take any medication in BWG is 60.8% vs. 40% in CG;P = 0.029). Conclusion. Lumbar belt wearing is consequent in subacute low back pain to improve significantly the functional status, the pain level, and the pharmacologic consumption. This study may be useful to underline the interest of lumbar support as a complementary and nonpharmacologic treatment beside the classic medication use in low back pain treatment.

Bergström A., Maurel F., Le Pen C., Lamure E., Kent M., Bardoulat I., Berdeaux G. (2009), Daily costs of prostaglandin analogues as monotherapy or in fixed combinations with timolol, in Denmark, Finland, Germany and Sweden, Clinical Ophthalmology, 3, p. 471-481

Background: To compare the daily costs of 3 prostaglandin analogues (bimatoprost, latanoprost, travoprost), alone, and associated with timolol in 4 European countries (Denmark, Finland, Germany, and Sweden). Methods: Six glaucoma products were sampled by buying 5 bottles from 1 suburban pharmacy in each of the 4 countries. Drops were weighed by a single operator at 1 site according to standardized procedures. Residual drops were then counted. Unit bottle costs were estimated from tariff lists. Eye-drop weights were entered into a nested analysis of variance comprising drug, instillation day, country, the interaction, and a sample factor nested within the country factor. Effectiveness was represented by treatment failure rates estimated from a meta-analysis and a general practitioner survey. Results: Every drug bottle contained sufficient drops to treat 1 patient for 28/31 days. Drop-size heterogeneity between countries was observed for bimatoprost and bimatoprost/timolol. Mean travoprost and travoprost/timolol drop-sizes were the smallest, and drop-counts per bottle were the lowest for latanoprost, or latanoprost/timolol. In all 4 countries annual costs were least for travoprost and travoprost/timolol. Conclusions: On taking into account drug costs and effectiveness, travoprost and travoprost/timolol were cheaper and more effective than latanoprost and latanoprost/timolol and were cheaper than bimatoprost and bimatoprost/timolol.

Chevaleyre Y., Dunne P., Endriss U., Lang J., Lemaître M., Maudet N., Padget J., Phelps S., Rodríguez-Aguilar J., Sousa P. (2006), Issues in Multiagent Resource Allocation, Informatica, 30, 3, p. 3-31

The allocation of resources within a system of autonomous agents, that not only havepreferences over alternative allocations of resources but also actively participate in com-puting an allocation, is an exciting area of research at the interface of Computer Scienceand Economics. This paper is a survey of some of the most salient issues in MultiagentResource Allocation. In particular, we review various languages to represent the pref-erences of agents over alternative allocations of resources as well as different measuresof social welfare to assess the overall quality of an allocation. We also discuss pertinentissues regarding allocation procedures and present important complexity results. Ourpresentation of theoretical issues is complemented by a discussion of software packagesfor the simulation of agent-based market places. We also introduce four major applica-tion areas for Multiagent Resource Allocation, namely industrial procurement, sharingof satellite resources, manufacturing control, and grid computing

Amouretti M., Le Pen C., Gaudin A-F., Bommelaer G., Frexinos J., Ruszniewski P., Poynard T., Maurel F., Priol G., El Hasnaoui A. (2006), Impact of irritable bowel syndrome (IBS) on health-related quality of life (HRQOL), Gastroentérologie clinique et biologique, 30, 2, p. 241-246

Objectif : Evaluer l'impact du syndrome de l'intestin irritable (SII) sur la qualité de vie (QdV) des malades. Méthode : Deux échelles de QdV ont été administrées par voie téléphonique à un échantillon de 253 malades français atteints de SII recrutés en population générale. Le SII a été diagnostiqué à partir des critères de Manning, Rome I et Rome II. Les malades qui présentaient une maladie organique étaient exclus de l'étude. Une échelle générique, la SF-36 et une échelle spécifique, l'IBSQOL, ont été utilisés. Résultats : Chez les malades avec SII, les scores de QdV étaient significativement inférieurs (p < 0,05) pour toutes les dimensions de l'échelle SF-36 comparés à ceux observés en population générale. Les femmes (N = 192) présentaient une QdV significativement plus détériorée (p < 0,05) que les hommes (N = 61) pour les deux échelles et dans toutes leurs dimensions à l'exception de la dimension « vitalité » de l'échelle SF-36 et de la dimension « sommeil » de l'IBSQOL. La QdV se dégradait avec l'ancienneté des troubles pour certaines dimensions telles que les habitudes alimentaires. Pour les deux instruments, une corrélation positive entre les faibles scores de QdV des malades et l'intensité des douleurs ou gênes a pu être observée. La QdV des malades avec prédominance de diarrhée (N = 72) était significativement plus dégradée que celle des sujets à prédominance de constipation (N = 65) pour la dimension « état émotionnel » (P _ 0,05). Conclusion : Le SII a un fort impact sur la QdV des malades. Des caractéristiques spécifiques tels que le sexe féminin, la sévérité des symptômes ainsi que l'ancienneté des troubles peuvent prédire une qualité de vie encore plus détériorée.

Aims: To assess the impact of irritable bowel syndrome (IBS) on patient-reported health-related quality of life (HRQOL). Methods: Two HRQOL instruments were administered by telephone interviews to a sample of 253 IBS French patients recruited from the general population. IBS was diagnosed according to the Manning, Rome I and Rome II criteria. Patients with organic diseases were excluded from the study. A generic instrument, the Short Form 36 (SF-36), and an IBS disease-specific instrument, the IBSQOL, were used. Results: Patients with IBS had statistically significant (P &lt; 0.05) lower scores for all SF-36 QOL domains compared with the general French population. Women (N = 192) reported significantly (P &lt; 0.05) poorer HRQOL on both the SF-36 and the IBSQOL scores than men (N = 61) for all domains except energy on the SF36 and the sleep on the IBSQOL. HRQOL deteriorated with time since onset of IBS symptoms for some domains such as diet. For both instruments, a positive correlation was observed between low scores and intensity of pain and discomfort. IBS patients with a predominance of diarrhea (N = 72) exhibited significantly greater impairment of HRQOL in the emotional domain than IBS persons with constipation predominance (N = 65) (P<=0.05). Conclusion: IBS has a significant impact on HRQOL of patients. In addition, specific characteristics such as gender, symptom severity and time since onset of symptoms are predictive of more impaired health-related quality of life.


Blecic I., Canu D., Cecchini A., Congiu T., Fancello G., Mauro S., Sacerdotti S., Trunfio G. (2016), Coupling Surveys with GPS Tracking to Explore Tourists' Spatio-Temporal Behaviour, Computational Science and Its Applications - ICCSA 2016 (16th International Conference), Beijing, China

Position tracking technologies developed in the last decade are a valuable addition to the traditional toolbox for data collection, as they offer the opportunity to gather a great amount of unprecedented information on tourists behaviour. In particular, they allow to collect detailed information on spatial and temporal behaviour with respect to different categories/profiles of tourists. We present the results of a survey of tourists' spatial behaviour coupling GPS movement tracking and questionnaires, and furthermore discuss how this kind of studies may prove useful in providing guidelines for territorial, tourist and transportation policies.

Ould Ahmed P., Marques-Pereira J., Le Maux L., Desmedt L., Blanc J., Théret B. (2013), Monetary plurality in economic theory, 17th Annual Conference of the European Society for the History of Economic Thought, Londres, Royaume-Uni

The objective of this article is to identify the monetary plurality in economic theory. We will try to throw light on the way in which theories are attracted towards both unicity and plurality, and more specifically by unification and diversification of money. It should also be noted, in this respect, that the economics of money has undergone considerable development since the 1970s. A survey of the diverse theories, whether mainstream or not, static or dynamic, holistic or individualistic, will reveal the surprising amount of attention devoted to the problem of monetary unicity and/or plurality. We base our presentation on two lines of thought: -The first of these lines concerns a situation of general equilibrium, as opposed to theories giving place to the forms of disequilibrium and regime-crises. The general equilibrium theories usually see money as a financial asset and assume that it is neutral at least over the long term; theories of the second type, on the contrary, see money as a necessary condition for the development of trade, acknowledging that it influences the system of relative prices and consequently the dynamics of production. Thus money is presumed to be totally neutral ("super-neutral") in the New Classical Economics in the manner of Lucas (1972, 1995) and in the New Monetary Economics initiated by Black (1970) and Fama (1980). On the contrary, it is not neutral according to neo-Mengerian approaches and to those that are neo-Marxist, Chartalist and post-Keynesian. -The second line of thinking revolves round the relationship between economic theories and the question of the unicity or plurality of money as a norm to be established. This relationship is often linked to the role assigned by the various approaches to finance. For example, the macroeconomics of the New Classical Economics school, in dealing with monetary "friction" within general equilibrium theory, maintains an approach that is largely "unitary", seeking to integrate it into its framework. In this respect it opposes the financial views of the New Monetary Economics, that are based on a pluralist notion of money, aiming moreover to ensure that it could be dispensed it with the world of reality. Similarly, neo-Mengerian economists, who are pluralist and see financing as the heart of the proper organisation of money, are opposed to the unitarian approaches of Marxist, Chartalist and post-Keynesian economists. Our survey of contemporary theories will give rise to a typology of the forms of monetary unicity and plurality, framing a new reading of monetary theories.

Le Pen C., Schadtler Law L., Camara C., Bardoulat I., Maurel F. (2009), Indirect costs of rheumatoid arthritis and their Determinants, ISPOR 12th Annual European congress, Paris, France

Le Pen C., Schadtler Law L., Camara C., Preiss P., Bardoulat I., Maravic M., Fautrel B., Maurel F. (2009), Impact of rheumatoid arthritis (ra) on working conditions and income, ISPOR 12th Annual European congress, Paris, France

Le Pen C., Miadi-Fargier H., Fautrel B., Maravic M., Daures J., Ollivier A., Maurel F. (2008), Cost-effectiveness of using etanercept as first Line in severe and highly active rheumatoid Arthritis (ra), ISPOR 11th Annual European Congress : "Moving and Improving Concepts & Evidence for Health Care Decisions", Athènes, Grèce

Feneron D., Daures J., Ollivier A., Thiriet C., Maurel F., Ortonne J., Le Pen C. (2008), Cost-effectiveness of etanercept and efalizumab In the management of moderate and severe plaque psoriasis, ISPOR 11th Annual European Congress : "Moving and Improving Concepts & Evidence for Health Care Decisions", Athènes, Grèce

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